This informal CPD article ‘Pregnancy Vaccines: Protecting You and Your Baby’ was provided by Cima Care, who offer extensive training in vaccination and public health, advancing global health initiatives.
In the following hypothetical example, when Maria discovered she was pregnant with her second child, one of her first concerns was about vaccinations. "Are they safe during pregnancy?" she wondered. "Will they actually help protect my baby?" Like many expecting mothers, Maria had heard conflicting information and wanted clear, reliable answers.
The good news is that science has started to provide answers, and the evidence is genuinely reassuring for parents seeking clarity.
Nature's Amazing Protection System
Your body has an incredible built-in protection system for your growing baby. During pregnancy, special proteins called antibodies travel from your bloodstream through the placenta to your baby. Think of these antibodies as tiny bodyguards that teach your baby's immune system how to recognise and fight off dangerous infections.
This amazing process becomes much more efficient after 28 weeks of gestation, with the highest level of protection happening during your third trimester. 1&2 It's like nature's way of ensuring your baby gets the best possible start in life.
Timing Matter for Maximum Protection
Recent research has shown that the timing of vaccination during pregnancy can impact the level of protection your baby receives. For example, if you receive a Respiratory Syncytial virus (RSV) vaccine at least 5 weeks before delivery, your baby will receive better protection than if you wait until closer to your due date. 3
Investigation shows that for COVID-19 vaccines, getting vaccinated in the early third trimester (around weeks 27-31) gives your baby about 2.3 times more protection compared to vaccination later in pregnancy. 4
The Four Key Vaccines That Protect Both Mother and Baby
1- COVID-19 Vaccination
Despite changing policies, major medical organisations continue to support COVID-19 vaccination during pregnancy. 5 The American College of Obstetricians and Gynecologists has emphasised that COVID-19 infection during pregnancy can be devastating. 6
Studies of pregnant women show that COVID-19 vaccines are safe during pregnancy. 7 When mothers complete their two-dose vaccine series during pregnancy, their babies are 61% less likely to be hospitalised for COVID-19 in their first six months of life. This protection jumps to 80% when vaccination happens later in pregnancy. 8
In fact, babies born to vaccinated mothers who received mRNA COVID-19 vaccines during pregnancy often have better health outcomes, including lower rates of severe illness and fewer intensive care admissions, compared to babies of unvaccinated mothers. 24
2-Flu Vaccination
Getting a flu shot during pregnancy is one of the most essential things you can do for both you and your baby. Pregnancy makes you more vulnerable to severe flu complications, but vaccination can reduce your risk of flu-related hospitalisation by 50-70%. 9
Your baby also benefits tremendously. The antibodies you develop protect your infant for up to 6 months after birth, reducing their risk of severe respiratory illness by about 64% and hospitalisation by 67%. 10
3-Tdap Vaccination
The Tdap vaccine protects against tetanus, diphtheria, and pertussis (also known as whooping cough). When given during the third trimester, it provides excellent protection for your newborn against these serious diseases. 11, 12,13
Studies show that 62% to 100% of babies born to vaccinated mothers have protective levels of antibodies against tetanus and diphtheria, depending on exactly when during pregnancy the vaccine was given. 11
4-RSV Vaccination
RSV vaccination is one of the newest recommendations for pregnant women. RSV vaccine, administered between 32 and 36 weeks of pregnancy, can reduce the risk of severe respiratory infection in babies by 81.8% within the first 90 days of life and 69.4% within 180 days after birth, compared to the placebo. 14, 15, 16
Scientists working on new vaccines
Addressing Common Concerns
Are these vaccines really safe during pregnancy?
Extensive studies involving pregnant women have consistently shown that recommended vaccines are safe during pregnancy. There is no increased risk of miscarriage, preterm birth, birth defects, or other complications. 16-23
Should I be worried about side effects?
Like any medical intervention, vaccines can cause mild side effects such as soreness at the injection site or low-grade fever. If you have diabetes or other health conditions, these temporary effects may slightly affect your blood sugar levels, so it's advisable to monitor them more closely on vaccination day. 23, 25
The Power of Shared Protection
Evidence indicates that vaccination during pregnancy can be one of the most effective ways to protect both you and your baby from serious diseases. The antibodies you develop not only protect you but also create a shield of protection around your newborn during those vulnerable first months of life, when their own immune system is still developing.
Key takeaways for expecting parents:
- Vaccines recommended during pregnancy are safe and highly effective.
- Your baby receives months of protection through the antibodies you develop.
- Timing matters—discuss the optimal schedule with your healthcare provider.
- The benefits far outweigh any minimal risks. 26-33
Looking to the Future
Scientists are working on new vaccines that could protect even more mothers and babies in the future. Vaccines for Group B Streptococcus and cytomegalovirus are in advanced testing and could prevent infant deaths and serious complications worldwide. 9, 29 & 31-33
Remember, every pregnancy is unique. While the science supports vaccination during pregnancy, it is essential to discuss your specific situation with your healthcare provider to make informed decisions for you and your growing family.
Research is reassuring: by choosing to vaccinate during pregnancy, you are giving your baby protection against serious diseases from their very first breath. 34
We hope this article was helpful. For more information from Cima Care, please visit their CPD Member Directory page. Alternatively, you can go to the CPD Industry Hubs for more articles, courses and events relevant to your Continuing Professional Development requirements.
REFERENCES
1- Borghi S, Bournazos S, Thulin NK, Li C, Gajewski A, Sherwood RW, Zhang S, Harris E, Jagannathan P, Wang LX, Ravetch JV. FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies. Proceedings of the National Academy of Sciences. 2020 Jun 9;117(23):12943-51.
2- Mahant AM, Trejo FE, Aguilan JT, Sidoli S, Permar SR, Herold BC. Antibody attributes, Fc receptor expression, gestation and maternal SARS-CoV-2 infection modulate HSV IgG placental transfer. Iscience. 2023 Sep 15;26(9).
3- JASSET OJ, Andrea P, Zeynep BAHADIR, SHOOK L, DENNIS M, GILBERT E, et al. Enhanced placental antibody transfer efficiency with longer interval between maternal RSV vaccination and birth. American Journal of Obstetrics and Gynecology. 2024 Nov 1;
4- Rottenstreich A, Zarbiv G, Oiknine-Djian E, Vorontsov O, Zigron R, Kleinstern G, et al. Timing of SARS-CoV-2 vaccination during the third trimester of pregnancy and transplacental antibody transfer: a prospective cohort study. Clinical Microbiology and Infection. 2021 Nov;
5- Apoorva Mandavilli, Jewett C. U.S. Will No Longer Recommend Covid Shots for Children and Pregnant Women. The New York Times [Internet]. 2025 May 27; Available from: https://www.nytimes.com/2025/05/27/health/covid-vaccines-children-pregnant-women-rfk-jr.html
6- ACOG Statement on HHS Recommendations Regarding the COVID Vaccine During Pregnancy [Internet]. Acog.org. 2025. Available from: https://www.acog.org/news/news-releases/2025/05/acog-statement-on-hhs-recommendations-regarding-the-covid-vaccine-during-pregnancy
7- Prasad S, Kalafat E, Blakeway H, Townsend R, O’Brien P, Morris E, et al. Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy. Nature Communications. 2022 May 10;13(1).
8- Halasa NB. Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19–Associated Hospitalization in Infants Aged 6 Months — 17 States, July 2021–January 2022. MMWR Morbidity and Mortality Weekly Report [Internet]. 2022;71. Available from: https://www.cdc.gov/mmwr/volumes/71/wr/mm7107e3.htm
9- Santilli V, Sgrulletti M, Costagliola G, Beni A, Mastrototaro MF, Montin D, et al. Maternal Immunization: Current Evidence, Progress, and Challenges. Vaccines. 2025 Apr 24;13(5):450.
10- Fell DB, Russell M, Fung SG, Swayze S, Chung H, Buchan SA, Roda W, Smolarchuk C, Wilson K, Crowcroft NS, Schwartz KL. Effectiveness of influenza vaccination during pregnancy against laboratory-confirmed seasonal influenza among infants under 6 months of age in Ontario, Canada. The Journal of infectious diseases. 2024 Jul 15;230(1):e80-92.
11- Post AL, Li SH, Berry M, Itell H, Martinez DR, Xie G, et al. Efficiency of placental transfer of vaccine-elicited antibodies relative to prenatal Tdap vaccination status. Vaccine. 2020 Jun;38(31):4869–76.
12- Hanoi V. Maternal immunization: current status and future directions Vaccinology 2017 III International Symposium for Asia Pacific Experts [Internet]. 2017 [cited 2025 Jul 20]. Available from: https://www.fondation-merieux.org/wp-content/uploads/2017/10/vaccinology-2017-deshayne-fell.pdf
13- Fakhraei R, Crowcroft N, Bolotin S, Sucha E, Hawken S, Wilson K, et al. Obstetric and perinatal health outcomes after pertussis vaccination during pregnancy in Ontario, Canada: a retrospective cohort study. CMAJ Open. 2021 Apr;9(2):E349–9.
14- FDA. FDA Approves First Vaccine for Pregnant Individuals to Prevent RSV in Infants [Internet]. FDA. 2023. Available from: https://www.fda.gov/news-events/press-announcements/fda-approves-first-vaccine-pregnant-individuals-prevent-rsv-infants
15- CDC. RSV Vaccine Guidance for Pregnant People [Internet]. Respiratory Syncytial Virus Infection (RSV). 2024. Available from: https://www.cdc.gov/rsv/hcp/vaccine-clinical-guidance/pregnant-people.html
16-Maternal Respiratory Syncytial Virus Vaccination [Internet]. www.acog.org. Available from: https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2023/09/maternal-respiratory-syncytial-virus-vaccination
17- Getahun D, Liu ILA, Sy LS, Glanz JM, Zerbo O, Vazquez-Benitez G, et al. Safety of the Seasonal Influenza Vaccine in 2 Successive Pregnancies. JAMA Network Open. 2024 Sep 19;7(9):e2434857–7.
18- CDC. Flu Vaccine Safety and Pregnancy [Internet]. Influenza (Flu). 2024. Available from: https://www.cdc.gov/flu/vaccine-safety/vaccine-pregnant.html
19- Vaccines [Internet]. www.who.int. Available from: https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics/pregnancy-and-lactation/vaccines
20- Greenberg V, Vazquez-Benitez G, Kharbanda EO, Daley MF, Hung Fu Tseng, Klein NP, et al. Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes. Vaccine. 2023 May 1;41(22):3429–35.
21- Shi Q, Li J, Hu Q, Cheng C, Yang K, Li X, et al. Efficacy, Immunogenicity, and Safety of Pertussis Vaccine During Pregnancy: A Meta-Analysis. Vaccines [Internet]. 2025 Jun 20 [cited 2025 Jul 14];13(7):666–6. Available from: https://www.mdpi.com/2076-393X/13/7/666
22- Chittajallu LVS, Kaku R, Kondadasula P, Lim JY, Zhumabekova A. Safety and Efficacy of Vaccines During Pregnancy: A Systematic Review. Cureus. 2025 Jan 9;
23- Odette de Bruin, Phijffer E, Fariba Ahmadizar, van, Wildenbeest J, Sturkenboom M, et al. Are maternal vaccines effective and safe for mothers and infants? A systematic review and meta-analysis of randomised controlled trials. BMJ Global Health. 2023 Oct 1;8(10):e012376–6.
24-Jorgensen SCJ, Drover SSM, Fell DB, Austin PC, D’Souza R, Guttmann A, et al. Newborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy. JAMA Pediatrics [Internet]. 2023 Oct 23; Available from: https://jamanetwork.com/journals/jamapediatrics/fullarticle/2810937
25-Paterson J. Whooping cough and flu vaccinations • Gestational Diabetes UK [Internet]. Gestational Diabetes UK. 2020 [cited 2025 Aug 31]. Available from: https://www.gestationaldiabetes.co.uk/whooping-cough-and
26- Joel B, Moses V, Veeraraghavan B, Santhanam S, Beck MM, Dhar N, et al. Group B Streptococcus Vaccine Update: A Crucial Public Health Initiative for India. Indian Journal of Medical Microbiology [Internet]. 2025 Jul 11;100917. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0255085725001306
27- Vaccine profiles: Group B streptococcus (GBS) [Internet]. www.gavi.org. Available from: https://www.gavi.org/vaccineswork/routine-vaccines-extraordinary-impact-group-b-streptococcus-gbs
28- Maternal, Neonatal, and Early Infancy Vaccine Developments - NYAS [Internet]. NYAS - The New York Academy of Sciences. 2020 [cited 2025 Jul 14]. Available from: https://www.nyas.org/shaping-science/events/ebriefing/maternal-neonatal-and-early-infancy-vaccine-developments/
29- February 2025 [Internet]. [cited 2025 Jul 14]. Available from: https://media.path.org/documents/Feb2025_MovingTheNeedle.pdf
30- New Targets Needed for Vaccine that Blocks Maternal Herpesvirus Transmission [Internet]. WCM Newsroom. Weill Cornell Medicine; 2025 [cited 2025 Jul 14]. Available from: https://news.weill.cornell.edu/news/2025/03/new-targets-needed-for-vaccine-that-blocks-maternal-herpesvirus-transmission
31- Permar SR, Schleiss MR, Plotkin SA. A vaccine against cytomegalovirus: how close are we? Journal of Clinical Investigation. 2025 Jan 2;135(1).
32- Paris R. Overview of mRNA-1647: Investigational CMV Vaccine ACIP [Internet]. 2025 [cited 2025 Jul 14]. Available from: https://www.cdc.gov/acip/downloads/slides-2025-04-15-16/03-paris-CMV-508.pdf
33- Dr. Chinta Sidharthan. News-Medical [Internet]. News-Medical. 2025. Available from: https://www.news-medical.net/news/20250106/Decades-of-research-push-cytomegalovirus-vaccine-closer-to-reality.aspx
34- CDC. Vaccine Safety for Moms-To-Be [Internet]. Pregnancy and Vaccination. 2024. Available from: https://www.cdc.gov/vaccines-pregnancy/moms-to-be/index.html
